Dr. Ryan P. Bennett

The People of OyaGen

Dr. Ryan P. Bennett, Chief Scientific Officer and Laboratory Director

Ryan P. Bennett

Ryan Bennett joined OyaGen in 2007. Dr. Bennett earned his BS in Biology/Chemistry from Elmira College in 2001 and his PhD from the Department of Biochemistry at the University of Rochester, School of Medicine and Dentistry in 2007.

He received a National Institute of Health HIV Training Grant Fellowship in 2005, 2006, and 2007. He also received an RNA Society award for best graduate student poster at the Gordon Research Conference on RNA Editing in January 2007. He pursued his graduate research on the multifaceted functions of the HIV-1 antiviral protein APOBEC3G under the direction of Professor Harold C. Smith the founder of OyaGen.

Ryan’s focus at OyaGen is on assay development around the APOBEC3G/Vif platform and secondary analysis of small molecule hits from High Throughput Screening.

Publications

Bennett RP, Salter JD, Liu X, Wedekind JE, Smith HC. APOBEC3G subunits self-associate via the C-terminal deaminase domain. J Biol Chem in press (2008).

Bennett RP, Presnyak V, Wedekind JE, Smith HC. Nuclear exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal. J Biol Chem 283, 7320-7(2008).

Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC. APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic. Biochem Biophys Res Commun 350, 214-9 (2006).

Wedekind JE, Gillilan R, Janda A, Krucinska J, Salter JD, Bennett RP, Raina J, Smith HC. Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits. J Biol Chem 281, 38122-6 (2006).

Jin X, Brooks A, Chen H, Bennett R, Reichman R, and Smith H. APOBEC3G/CEM15 (hA3G) mRNA Levels Associate Inversely with Human Immunodeficiency Virus Viremia. J Virol 79, 11513-6 (2005).

Tomari Y, Du T, Haley B, Schwarz DS, Bennett R, Cook HA, Koppetsch BS, Theurkauf WE, Zamore PD. RISC Assembly Defects in the Drosophila RNAi Mutant armitage. Cell 116, 831-41 (2004).